Abstract: Scleral remodeling is the key to the onset and development of myopia, and scleral fibroblasts play an important role in scleral remodeling. During scleral remodeling, scleral fibroblasts showed an anti-fibrosis, contractile and pro-inflammatory phenotype with low synthesis and high degradation of extracellular matrix components. Currently, hypoxia stimulation, cyclic adenosine monophosphate (cAMP) catabolism, and matrix metalloproteinases (MMPs) expression are three main targets of myopic scleral fibroblasts. Notably, the antihypoxia drugs could reduce experimental myopia by regulating the hypoxia-inducible factor (HIF) signaling pathway, which is worthy of further study. (Int Rev Ophthalmol, 2023, 47: 79-84)

Key words: fibroblast, scleral remodeling, myofibroblast, myopia